Role of facilitative glucose transporters in diffusional water permeability through J774 cells.

Role of facilitative glucose transporters in diffusional water permeability through J774 cells

We have reported previously that in the presence of an osmotic gradient, facilitative glucose transporters (GLUTs) act as a transmembrane pathway for water flow. Here, we find evidence that they also allow water passage in the absence of an osmotic gradient. We applied the linear diffusion technique to measure the diffusional permeability (Pd) of tritiated water (3H-H2O) through plasma membrane...

Facilitative Glucose Transporters in Articular Chondrocytes - ReadingSample

Facilitative glucose transporters in livestock species.

The study of facilitative glucose transporters (GLUT) requires carefully done immunological experiments and sensitive molecular biology approaches to identify the various mechanisms which control GLUT expression at the RNA and protein levels. The cloning of species-specific GLUT cDNAs showed that GLUT4 and GLUT1 diverge less among species than other GLUT isoforms. The key role of GLUT in glucos...

Avian and Mammalian Facilitative Glucose Transporters

The GLUT members belong to a family of glucose transporter proteins that facilitate glucose transport across the cell membrane. The mammalian GLUT family consists of thirteen members (GLUTs 1-12 and H⁺-myo-inositol transporter (HMIT)). Humans have a recently duplicated GLUT member, GLUT14. Avians express the majority of GLUT members. The arrangement of multiple GLUTs across all somatic tissues ...

Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes.

Introduction Maintenance of normal glucose homeostasis results from the precise orchestration ofthree processes: glucose absorption via the gut, production by the liver, and utilization by nearly all tissues in the body. In the fasting state, most ofglucose utilization is by brain and is independent of insulin. Glucose levels are maintained during a fast by the tightly regulated release of gluc...